sixpenceee:

Displayed in the Saint-Étienne church in France is the figure of René de Chalon, Prince of Orange. The prince died at the young age of 25 during the siege of Saint-Dizier in 1544. 
Rather then memorialize him in the standard hero form, his wife requested (or René himself requested, or possibly both) that he be shown as “not a standard figure but a life-size skeleton with strips of dried skin flapping over a hollow carcass, whose right hand clutches at the empty rib cage while the left hand holds high his heart in a grand gesture.” (Source)

sixpenceee:

Displayed in the Saint-Étienne church in France is the figure of René de Chalon, Prince of Orange. The prince died at the young age of 25 during the siege of Saint-Dizier in 1544.

Rather then memorialize him in the standard hero form, his wife requested (or René himself requested, or possibly both) that he be shown as “not a standard figure but a life-size skeleton with strips of dried skin flapping over a hollow carcass, whose right hand clutches at the empty rib cage while the left hand holds high his heart in a grand gesture.” (Source)

9,347 notes

alexandraya:

superwholockey:

tanzanator:

bookworm-for-life:



Limits of the Human Body by Soda Pop Avenue


I am a writer I say as I reblog this

i am an a R TIST

FUCK THIS I’M A MURDERER

Let’s be honest, I’m a serial killer.

alexandraya:

superwholockey:

tanzanator:

bookworm-for-life:

Limits of the Human Body by Soda Pop Avenue

I am a writer I say as I reblog this

i am an a R TIST

FUCK THIS I’M A MURDERER

Let’s be honest, I’m a serial killer.

(Source: macapan)

247,814 notes

art-of-swords:

Katar Dagger

  • Dated: 17th–18th century
  • Place of Origin: Thanjavur
  • Culture: South Indian, Thanjavur
  • Medium: steel

An odd, yet very beautiful variation of a Katar dagger with an European blade.

Source: Copyright © 2014 The Metropolitan Museum of Art

2,922 notes

art-of-swords:

Bronze Dagger

  • Dated: 19th century
  • Medium: bronze
  • Measurements: overall length 23 cm

The handle of the dagger is ornate with a skeleton around which a snake is coiled.

Source: Copyright © 2014 Expertissim

3,165 notes

egberts:

snacklemore:

egberts:

my life in one picture

image

there is no picture

i have no life

330,307 notes

rollership:

An end to plastic packaging poisoning us and all the life that feeds off the ocean is very very possible.

worclipThis Too Shall Pass (2012) by Tomorrow Machine

Independent packaging project for perishable goods:

Is it reasonable that it takes several years for a milk carton to decompose naturally, when the milk goes sour after a week? This Too Shall Pass is a series of food packaging were the packaging has the same short life-span as the foods they contain. The package and its content is working in symbiosis.

Smoothie package
Gel of the agar agar seaweed and water are the only components used to make this package. To open it you pick the top. The package will wither at the same speed as its content. It is made for drinks that have a short life span and needs to be refrigerated, fresh juice, smoothies and cream for example.

Rice Package
Package made of biodegradable beeswax. To open it you peel it like a fruit. The package is designed to contain dry goods, for example grains and rice.

Oil package
A package made of caramelized sugar, coated with wax. To open it you crack it like an egg. When the material is cracked the wax do no longer protect the sugar and the package melts when it comes in contact with water. This package is made for oil-based food.

62,764 notes

mindblowingscience:

Schizophrenia is actually eight genetically distinct disorders, study reveals

Scientists have identified eight separate clusters of genetic variations that, together, carry a 70 to 100 percent risk of a patient developing a certain type of schizophrenia.
The discovery could revolutionise diagnosis and treatment for the debilitating psychiatric illness. Scientists already knew that around 80 percent of the risk of schizophrenia is inherited, but have struggled for decades to identify specific genes linked to the condition.
But a new approach has analysed the DNA of more than 4,000 people with the illness, and have identified that there are actually eight different classes of schizophrenia, each influenced by distinct gene clusters.
The research was led by scientists from the Washington University School of Medicine in St Louis in the US.
“Genes don’t operate by themselves,” said C. Robert Cloninger, one of the senior investigators,in a press release. “They function in concert much like an orchestra, and to understand how they’re working, you have to know not just who the members of the orchestra are but how they interact.”
To unravel these interactions, the scientists analysed the DNA variations between 4,200 people with schizophrenia and 3,800 people without the disease. They also matched these DNA variations to specific symptoms in individual patients.
After looking at 700,000 small changes in DNA, known as single nucleotide polymorphism (SNP), the scientists mapped which changes influenced which symptoms, and patterns began to emerge.
For example, in patients with hallucinations or delusions, they identified specific genetic variations that led to a 95 percent certainty of schizophrenia. And for patients who have disorganised speech and behaviour, they found a separate group of DNA variations that carried a 100 percent schizophrenia risk.
Overall, despite no single genetic changes being strongly linked to the disease on their own, the eight clusters the scientists identified all carried a 70 to 100 percent risk of developing schizophrenia. The results are published in The American Journal of Psychiatry.
As the press release explains, this makes it almost impossible for people with these genetic clusters to avoid the condition.
“What we’ve done here, after a decade of frustration in the field of psychiatric genetics, is identify the way genes interact with each other, how the ‘orchestra’ is either harmonious and leads to health, or disorganised in ways that lead to distinct classes of schizophrenia,” said Cloninger.
The scientists also went a step further and replicated their findings in two additional DNA databases of people with schizophrenia.
This work could now help researchers find targets for new drugs that could treat specific schizophrenia symptoms. And their DNA mapping technique could also be applied to help scientists find gene clusters that influence other diseases, such as cardiovascular disease and cancer.

mindblowingscience:

Schizophrenia is actually eight genetically distinct disorders, study reveals

Scientists have identified eight separate clusters of genetic variations that, together, carry a 70 to 100 percent risk of a patient developing a certain type of schizophrenia.

The discovery could revolutionise diagnosis and treatment for the debilitating psychiatric illness. Scientists already knew that around 80 percent of the risk of schizophrenia is inherited, but have struggled for decades to identify specific genes linked to the condition.

But a new approach has analysed the DNA of more than 4,000 people with the illness, and have identified that there are actually eight different classes of schizophrenia, each influenced by distinct gene clusters.

The research was led by scientists from the Washington University School of Medicine in St Louis in the US.

“Genes don’t operate by themselves,” said C. Robert Cloninger, one of the senior investigators,in a press release. “They function in concert much like an orchestra, and to understand how they’re working, you have to know not just who the members of the orchestra are but how they interact.”

To unravel these interactions, the scientists analysed the DNA variations between 4,200 people with schizophrenia and 3,800 people without the disease. They also matched these DNA variations to specific symptoms in individual patients.

After looking at 700,000 small changes in DNA, known as single nucleotide polymorphism (SNP), the scientists mapped which changes influenced which symptoms, and patterns began to emerge.

For example, in patients with hallucinations or delusions, they identified specific genetic variations that led to a 95 percent certainty of schizophrenia. And for patients who have disorganised speech and behaviour, they found a separate group of DNA variations that carried a 100 percent schizophrenia risk.

Overall, despite no single genetic changes being strongly linked to the disease on their own, the eight clusters the scientists identified all carried a 70 to 100 percent risk of developing schizophrenia. The results are published in The American Journal of Psychiatry.

As the press release explains, this makes it almost impossible for people with these genetic clusters to avoid the condition.

“What we’ve done here, after a decade of frustration in the field of psychiatric genetics, is identify the way genes interact with each other, how the ‘orchestra’ is either harmonious and leads to health, or disorganised in ways that lead to distinct classes of schizophrenia,” said Cloninger.

The scientists also went a step further and replicated their findings in two additional DNA databases of people with schizophrenia.

This work could now help researchers find targets for new drugs that could treat specific schizophrenia symptoms. And their DNA mapping technique could also be applied to help scientists find gene clusters that influence other diseases, such as cardiovascular disease and cancer.

147 notes

kilart:

princess of hell
@kilart74  
twitter, 

kilart:

princess of hell

@kilart74 

twitter, 

690 notes

mylittlenestofvipers:

noisebaptism:

molten-heart:

asylum-art:

Erevos Aether – Wake the Serpent Not

Erevos Aether’s AW 2014-15 collection, Wake the Serpent Not, contrasts sheer, romantic, fragile textures with armorlike iridescent leather and metallic elements. The architectural qualities of this tough, invulnerable aspect combine with its softer side to create a high sci-fi look that is dark and impressive.

I would look so hot in all of these

I want to live in this future.

Need

27,836 notes

umiko-hitara:

poisonpawz:

zftw:

voyagebysexualdiscovery:

Uh oh

wouldn’t that be awkward

Can I get some credible sources?

Here’s one

and another

and one more for the road

326,921 notes